Protease Inhibitor Side Effects

Proteinase inhibitors are a special group of plant proteins brought together due to a common ability to form stoichiometric complexes with proteinases which leads to competitive inhibition of catalytic activity. Most of the inhibitors are accompanied by side effects in long-term treatment.

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The authors have found that MG-132 protects against acute lung injury through inhibition of mTOR4EBP1EIF4E pathway.

Protease inhibitor side effects. Nausea and dizziness are potential side effects of protease inhibitors. Previously BASHH guidelines recommended the protease inhibitor lopinavirritonavir Kaletra in place of raltegravir but research shows that raltegravir causes fewer side-effects and fewer potential drug-drug interactions and is associated with better adherence than lopinavirritonavir. What Are the Potential Side Effects When Using Protease Inhibitors.

1Southwest CARE Center Santa Fe New Mexico 87505 USA. Confirmed potential side effects of protease inhibitors are. Common adverse events associated with protease inhibitors include gastrointestinal side effects diarrhea nausea vomiting and metabolic complications dyslipidemia insulin resistance.

Side effects of HIV PIs are stomach discomfort diarrhea weakness and headache. Some side effects of protease inhibitors may be severe. Comparison of neuropsychiatric side effects in an observational cohort of efavirenz- and protease inhibitor-treated patients.

The major metabolic side effects associated with HIV protease inhibitor therapy are lipodystrophy syndrome and insulin resistance. Symptoms of liver damage may include jaundice which is a yellowing of the skin or whites of the eyes pale-colored stool or dark-colored urine. Protease inhibitors can have side effects.

These side effects though uncommon require emergency medical care. PEP is therefore easier to take than it used to be. 13 This lipodystrophy is colloquially known as Crix belly after indinavir Crixivan.

Hawkins T1 Geist C Young B Giblin A Mercier RC Thornton K Haubrich R. For instance patients may develop insulin resistance that leads to type 2. The most significant being a condition called HIV protease inhibitor-induced metabolic syndrome which results in.

Proteinase inhibitors occur in plants of various taxonomic groups. 56 The possible mechanisms of the metabolic alternations caused by HIV protease inhibitors have been studied. Side effects Protease inhibitors can cause a syndrome of lipodystrophy hyperlipidemia diabetes mellitus type 2 and kidney stones.

In the HIV life cycle protease is an essential element for viral maturation. If this happens seek emergency medical care. Protease inhibitors PI drugs are antiviral drugs used to treat HIV and hepatitis C HCV viral infections.

Side effects of hep C protease inhibitors are dizziness diarrhea fatigue headache and nausea. Administration of HIV protease inhibitors while beneficial to AIDS patients often results in serious side effects. 46 rows Adverse effects associated with the use of protease inhibitors nausea vomiting and.

Side effects of protease inhibitors. 4 Irregularities in fat distribution throughout the body dyslipidemia and lipodystrophy. Also the effects of protease inhibitor MG-132 on sepsis-induced lung injury have been studied using a Sprague Dawley rat model.

Although the toxic effects of HIV protease inhibitors could result from drug-drug interactions and overdose the off-target adverse drug effects of therapeutic doses is a major concern in drug design. In the following paragraphs the possible off-target effects of HIV protease inhibitors are discussed.

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